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IBMX

Catalog #: 2845
18 Citations Datasheet
Catalog # Availability Size / Price Qty
2845/50
IBMX | CAS No. 28822-58-4 | Phosphodiesterase Inhibitors
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Description: PDE inhibitor (non-selective)

Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

Purity: ≥98%

Product Details
Citations (18)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.

Technical Data

M.Wt:
222.24
Formula:
C10H14N4O2
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
28822-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
    S Gulati, H Jin, I Masuho, T Orban, Y Cai, E Pardon, KA Martemyano, PD Kiser, PL Stewart, CP Ford, J Steyaert, K Palczewski
    Nat Commun, 2018;9(1):1996.
  2. cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
    Lepski et al.
    Front.Cell Neurosci., 2013;7:155
  3. Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
    Freitag et al.
    Eur.J.Pharmacol., 1998;354:67

Product Datasheets

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Citations for IBMX

The citations listed below are publications that use Tocris products. Selected citations for IBMX include:

18 Citations: Showing 1 - 10

  1. Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.
    Authors: An Et al.
    Elife  2019;8
  2. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
    Authors: Jewell Et al.
    Elife  2019;8
  3. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
    Authors: Patra Et al.
    Nat Cell Biol  2018;20:811
  4. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
    Authors: Burdyga Et al.
    Proc Natl Acad Sci U S A.  2018;115(28):E6497
  5. Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM.
    Authors: Demeautis Et al.
    Sci Rep  2017;7:41026
  6. Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium.
    Authors: Hernández-Cascales
    PeerJ  2017;5:e3113
  7. Crystal structure of the GLP-1 receptor bound to a peptide agonist.
    Authors: Jazayeri
    Nature  2017;546:254
  8. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
    Authors: Havekes Et al.
    J Neurosci  2016;36:8936
  9. Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions.
    Authors: Foster Et al.
    Sci Rep  2015;5:10839
  10. Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab  2015;308:E130

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