FIN 56
Chemical Name: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Purity: ≥98%
Biological Activity
FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemical genetics: Unraveling cell death mysteries.
Cotto-Rios and Gavathiotis
Nat.Chem.Biol., 2016;12:470 -
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.
Shimada et al.
Nat.Chem.Biol., 2016;12:497
Product Datasheets
Citation for FIN 56
The citations listed below are publications that use Tocris products. Selected citations for FIN 56 include:
1 Citation: Showing 1 - 1
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Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
Authors: Jeff Et al.
Elife 2020;9
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