Home / Actin-related Products / Cytochalasin D

Cytochalasin D

Catalog #: 1233
21 Citations Datasheet
Catalog # Availability Size / Price Qty
1233/1
1233/5
Cytochalasin D | CAS No. 22144-77-0 | Actin-related Products
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Description: Disrupts actin filament function
Alternative Names: Zygosporin A

Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

Purity: ≥95%

Product Details
Citations (21)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cytochalasin D is a potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.

Technical Data

M.Wt:
507.63
Formula:
C30H37NO6
Solubility:
Soluble to 5 mg/ml in ethanol with gentle warming and to 25 mg/ml in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
22144-77-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Specific pathways mediating inflammasome activation by Candida parapsilosis
    A Tóth, E Zajta, K Csonka, C Vágvölgyi, MG Netea, A Gácser
    Sci Rep, 2017;7(0):43129.
  2. Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific
    N Nishijima, T Hirai, K Misato, M Aoyama, E Kuroda, KJ Ishii, K Higashisak, Y Yoshioka, Y Tsutsumi
    Front Immunol, 2017;8(0):379.
  3. VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells
    V Aragon-San, SE Pohler, VJ Eswar, M Bierowski, EW Gomez, C Dong
    Sci Rep, 2017;7(0):45835.
  4. Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia
    Y Zorina, J Stricker, AO Caggiano, DC Button
    Sci Rep, 2018;8(1):9392.
  5. Ezrin promotes stem cell properties in pancreatic ductal adenocarcinoma
    VR Penchev, YT Chang, A Begum, T Ewachiw, C Gocke, J Li, RH McMillan, Q Wang, R Anders, L Marchionni, A Maitra, A Uren, Z Rasheed, W Matsui
    Mol. Cancer Res., 2019;0(0):.
  6. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  7. Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP.
    Carlier et al.
    J.Biol.Chem., 1986;261:2041
  8. Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells.
    Abedi and Zachary
    Biochem.Biophys.Res.Commun., 1998;245:646
  9. Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells.
    Stevenson and Begg
    J.Cell Sci., 1994;107:367

Product Datasheets

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Citations for Cytochalasin D

The citations listed below are publications that use Tocris products. Selected citations for Cytochalasin D include:

21 Citations: Showing 1 - 10

  1. Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments.
    Authors: Lee Et al.
    Nat Commun  2019;10:529
  2. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake.
    Authors: Diaz-Garcia Et al.
    Cell Metab  2017;26:361
  3. The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.
    Authors: Lopez-Escobar Et al.
    Proc Natl Acad Sci U S A  2015;8:157
  4. ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis.
    Authors: Yang Et al.
    Am J Physiol Cell Physiol  2015;6:e1780
  5. G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.
    Authors: Chen Et al.
    Elife  2015;4
  6. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
    Authors: Chambers Et al.
    Elife  2015;4
  7. Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina.
    Authors: Lahne Et al.
    J Neurosci  2015;35:15612
  8. Centrosomal nucleolin is required for microtubule network organization.
    Authors: Gaume Et al.
    Cell Cycle  2015;14:902
  9. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    Elife  2015;10:e0125974
  10. Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly.
    Authors: Weidert Et al.
    PLoS One  2014;9:e108092
  11. Osmotic surveillance mediates rapid wound closure through nucleotide release.
    Authors: Gault Et al.
    J Cell Biol  2014;207:767
  12. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    Cell Death Dis  2014;111:E5114
  13. Raman spectroscopic imaging of the whole Ciona intestinalis embryo during development.
    Authors: Nakamura Et al.
    PLoS One  2013;8:e71739
  14. Recombinant probes reveal dynamic localization of CaMKIIα within somata of cortical neurons.
    Authors: Mora Et al.
    J Neurosci  2013;33:14579
  15. Mitotic spindle orients perpendicular to the forces imposed by dynamic shear.
    Authors: Fernandez Et al.
    PLoS One  2012;6:e28965
  16. Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
    Authors: Jeyaraj Et al.
    Integr Biol (Camb)  2012;303:C499
  17. Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine.
    Authors: Subramanian Et al.
    J Immunol  2012;188:3223
  18. Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization.
    Authors: Lin Et al.
    PLoS One  2012;13:9097
  19. Endogenous patterns of mechanical stress are required for branching morphogenesis.
    Authors: Gjorevski and Nelson
    Biochem Biophys Res Commun  2010;2:424
  20. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction.
    Authors: Gomez Et al.
    Dis Model Mech  2010;110:44
  21. The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways.
    Authors: Bose and Thomas
    Int J Mol Sci  2009;379:594

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