Cytochalasin B
Chemical Name: (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
Purity: ≥98%
Biological Activity
Cytochalasin B is an inhibitor of actin polymerization. Inhibits cell division, migration and glucose transport. Causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping.
Theodoropoulos et al.
Biochem.Pharmacol., 1994;47:1875 -
Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line.
Whitesell et al.
Biochem.J., 2005;386:245 -
Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment.
Buldak et al.
Eur.J.Histochem., 2014;58:2408
Product Datasheets
Citations for Cytochalasin B
The citations listed below are publications that use Tocris products. Selected citations for Cytochalasin B include:
7 Citations: Showing 1 - 7
-
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation.
Authors: Stefanie M Et al.
Mol Neurodegener 2023;18:15
-
Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances.
Authors: David Ian Et al.
Arch Toxicol 2022;96:1455-1471
-
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues.
Authors: Ingrid Et al.
Dev Cell 2022;57:47-62.e9
-
ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells.
Authors: Maria F Et al.
Elife 2021;10
-
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
Authors: Zheng Et al.
Cell Rep 2019;28:3224-3237.e5
-
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.
Authors: Bernier Et al.
Cell Rep 2019;27:2895
-
Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake.
Authors: Diaz-Garcia Et al.
Cell Metab 2017;26:361
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Cytochalasin B
There are currently no reviews for this product. Be the first to review Cytochalasin B and earn rewards!
Have you used Cytochalasin B?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
