Crotonic Acid
Discontinued Product
6660 has been discontinued.
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Description: Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length
Chemical Name: (2E)-2-Butenoic acid
Purity: ≥99%
Biological Activity
Crotonic Acid is an induces histone modifications in chemically induced pluripotent stem cells (CiPSCs). Activates gene expression, facilitates telomere maintenance and increases telomere length, and enhances reprogramming of MEFs to iPSCs using a small molecule cocktail including valproic acid (Cat. No. 2815), CHIR 99021 (Cat. No. 4423), tranylcypromine (Cat. No. 3852), forskolin (Cat. No. 1099), AM 580 (Cat. No. 0760), EPZ 004777 (Cat. No. 5567), SGC 0946 (Cat. No. 4541) and PD 0325901 (Cat. No. 4192).Technical Data
M.Wt:
86.09
Formula:
C4H6O2
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
107-93-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Dynamics of telomere rejuvenation during chemical induction to pluripotent stem cells.
Fu et al.
Stem Cell Reports, 2018;11:70
Product Datasheets
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