BMX-IN-1
Chemical Name: N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
Purity: ≥98%
Biological Activity
BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Discovery of a selective irreversible BMX inhibitor for prostate cancer.
Liu et al.
ACS Chem.Biol., 2013;8:1423 -
BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways.
Li et al.
Oncotarget., 2017;8:49238
Product Datasheets
Citation for BMX-IN-1
The citations listed below are publications that use Tocris products. Selected citations for BMX-IN-1 include:
1 Citation: Showing 1 - 1
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Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening.
Authors: Rudolf Et al.
Cell Rep 2021;35:109233
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