BI 9564
Chemical Name: 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
Purity: ≥98%
Biological Activity
BI 9564 is a potent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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An Advanced Tool To Interrogate BRD9.
Karim and Schönbrunn
J.Med.Chem., 2016;59:4459 -
Structure-based design of an in vivo active selective BRD9 inhibitor
Martin et al.
J.Med.Chem., 2016;59:4462
Product Datasheets
Citation for BI 9564
The citations listed below are publications that use Tocris products. Selected citations for BI 9564 include:
1 Citation: Showing 1 - 1
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BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4.
Authors: Nasun Et al.
Proc Natl Acad Sci U S A 2022;119
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