AZM 475271
Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Purity: ≥99%
Biological Activity
AZM 475271 is a src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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IL-17E synergizes with EGF and confers in vitro resistance to EGFR-targeted therapies in TNBC cells
Y Merrouche, J Fabre, H Cure, C Garbar, C Fuselier, J Bastid, F Antonicell, R Al-Daccak, A Bensussan, J Giustinian
Oncotarget, 2016;7(33):53350-53361. -
Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.
Yezhelyev et al.
Clin.Cancer Res., 2004;10:8028 -
AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.
Summy et al.
Mol.Cancer Ther., 2005;4:1900 -
Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers
YM Yang, L Ye, F Ruge, Z Fang, K Ji, AJ Sanders, S Jia, C Hao, QP Dou, J Ji, WG Jiang
International Journal of Molecular Sciences, 2023;24(1):.
Product Datasheets
Citations for AZM 475271
The citations listed below are publications that use Tocris products. Selected citations for AZM 475271 include:
4 Citations: Showing 1 - 4
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Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2.
Authors: Wang Et al.
Br J Pharmacol 2016;173:3342
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Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Authors: Gautam Et al.
Mol Cancer 2016;15:75
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Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
Authors: Thakur Et al.
Sci Rep 2015;5:10194
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Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
Authors: Leoni Et al.
J Clin Invest 2013;123:443
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