Mouse IGFBP-3 Biotinylated Antibody Summary
Pro22-Gln291 (Arg250Gln, Gln259Arg, Ser250Gly, and Arg271Pro)
Accession # P47878
Applications
Mouse IGFBP-3 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IGFBP-3
The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF.
Mouse IGFBP-3 cDNA encodes a 291 amino acid (aa) residue precursor protein with a putative 27 aa residue signal peptide that is processed to generate the 264 aa residue mature protein with three potential N-linked glycosylation sites. Mouse and human IGFBP-3 share 81% amino acid homology. Mouse IGFBP-3 is expressed in multiple tissues.
Product Datasheets
Citations for Mouse IGFBP-3 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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IGFBP-3 is a metastasis suppression gene in prostate cancer.
Authors: Mehta HH, Gao Q, Galet C
Cancer Res., 2011-06-22;71(15):5154-63.
Species: Mouse
Sample Types: Serum
Applications: ELISA Development -
Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.
Authors: Yamada PM, Mehta HH, Hwang D
Endocrinology, 2010-10-06;151(12):5741-50.
Species: Mouse
Sample Types: Serum
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Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
Authors: Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glode LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R
Cancer Res., 2007-11-15;67(22):11083-91.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development -
The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.
Authors: Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, LeRoith D, Rosen CJ
J. Endocrinol., 2006-05-01;189(2):289-99.
Species: Mouse
Sample Types: Serum
Applications: ELISA Development
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