Mouse CCL21/6Ckine Biotinylated Antibody Summary
Ser24-Gly133
Accession # P84444
Applications
Mouse CCL21/6Ckine Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL21/6Ckine
6Ckine is a novel CC chemokine discovered independently by three groups from the EST database. 6Ckine, also named SLC (secondary lymphoid-tissue chemokine), CCL21 and Exodus-2, shows 21 - 33% identity to other CC chemokines. 6Ckine contains the four conserved cysteines characteristic of beta chemokines plus two additional cysteines in its unusually long carboxyl-terminal domain. Human 6Ckine cDNA encodes a 134 amino acid residue, highly basic, precursor protein with a 23 amino acid residue signal peptide that is cleaved to form the predicted 111 amino acid residue mature protein. Mouse 6Ckine cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity. 6Ckine is constitutively expressed at high levels in lymphoid tissues such as lymph nodes, spleen and appendix. In mouse, high levels of 6Ckine mRNA are also detected in the lung. The gene for human 6Ckine has been localized at human chromosome 9p13 rather than chromosome 17 where the genes of many human CC chemokines are clustered. The 6Ckine gene location is within a region of about 100 kb from the MIP-3 beta /ELC gene, another identified novel CC chemokine.
Unlike most CC chemokines, 6Ckine is not chemotactic for monocytes. 6Ckine has also been reported to inhibit hemopoietic progenitor colony formation in a dose-dependent manner. 6Ckine acts via a class of as yet unidentified CC receptors on both T cells and B cells that are not shared by any other CC chemokines.
- Hedrick, J.A. and A. Zlotnik (1997) J. Immunol. 159:1589.
- Hromas, R. et al. (1997) J. Immunol. 159:2554.
- Nagira, M. et al. (1997) J. Biol. Chem. 272:19518.
Product Datasheets
Citations for Mouse CCL21/6Ckine Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones
Authors: Anne Chauveau, Gabriela Pirgova, Hung-Wei Cheng, Angelina De Martin, Felix Y. Zhou, Sarah Wideman et al.
Immunity
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CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth
Authors: Miyamoto, M;Kawato, Y;Fujie, R;Kurowarabe, K;Fujiwara, K;Nobusawa, R;Hayashi, R;Iida, K;Ohigashi, I;Hayasaka, H;
Cancer science
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Capture -
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Authors: A Prados, L Onder, HW Cheng, U Mörbe, M Lütge, C Gil-Cruz, C Perez-Shib, V Koliaraki, B Ludewig, G Kollias
Nature Immunology, 2021-03-11;0(0):.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Flow Cytometry, IHC -
Colonic patch and colonic SILT development are independent and differentially regulated events.
Authors: Baptista A, Olivier B, Goverse G, Greuter M, Knippenberg M, Kusser K, Domingues R, Veiga-Fernandes H, Luster A, Lugering A, Randall T, Cupedo T, Mebius R
Mucosal Immunol, 2012-09-19;6(3):511-21.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.
Authors: St John AL, Abraham SN
Nat. Med., 2009-10-25;15(11):1259-65.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult.
Authors: Roberts NA, Desanti GE, Withers DR, Scott HR, Jenkinson WE, Lane PJ, Jenkinson EJ, Anderson G
Eur. J. Immunol., 2009-09-01;39(9):2395-402.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking.
Authors: Jin Y, Shen L, Chong EM
Mol. Vis., 2007-04-27;13(0):626-34.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.
Authors: Tolba KA, D†ÃÅê†Ò, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD
Îζ)Š4wJ]¾b.ŠKd•ÿ¶fäMò&¨k³, 2002-11-15;62(22):6545-51.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment.
Authors: Janatpour MJ, Hudak S, Sathe M, McEvoy LM
J. Exp. Med., 2001-11-05;194(9):1375-84.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Essential Role of Canonical NF-kappa B Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
Authors: Dana Bogdanova, Arata Takeuchi, Madoka Ozawa, Yasuhiro Kanda, M. Azizur Rahman, Burkhard Ludewig et al.
The Journal of Immunology
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