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Recombinant Mouse CCL17/TARC Protein

Catalog #: 529-TR
13 Citations 1 Review Datasheet

Carrier Free

Catalog # Availability Size / Price Qty
529-TR-025/CF

With Carrier

Catalog # Availability Size / Price Qty
529-TR-025
R&D Systems Recombinant Proteins and Enzymes
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Product Details
Citations (13)
FAQs
Reviews (1)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse CCL17/TARC Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR4. The ED50 for this effect is 0.300-3.00 ng/mL.
Source
E. coli-derived mouse CCL17/TARC protein
Ala24-Pro93
Accession #
Q9WUZ6
N-terminal Sequence
Analysis
Ala24
Predicted Molecular Mass
7.9 kDa

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529-TR (with carrier)

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529-TR/CF (carrier free)

Product Datasheet

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

529-TR

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

529-TR/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CCL17/TARC

Human thymus and activation-regulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse TARC was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse TARC cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, TARC has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1 alpha, MIP-1 beta, MCP-1, MCP-2, MCP-3 and I-309. The gene for human TARC has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse TARC is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant TARC has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, TARC was identified to be a specific functional ligand for CCR-4 and CCR-8, receptors that are selectively expressed on T cells.

References
  1. Imai, T. et al. (1997) J. Biol. Chem. 272:15036.
  2. Imai, T. et al. (1996) J. Biol. Chem. 271:21514.
  3. Nomiyama, H. et al. (1997) Genomics 40:211.
  4. Lieberam, I. et al. (1999) Eur. J. Immunol. 29:2684.
Entrez Gene IDs
6361 (Human); 20295 (Mouse)
Alternate Names
ABCD-2; CC chemokine TARC; C-C motif chemokine 17; CCL17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARC; TARCA-152E5.3; Thymus and activation-regulated chemokine

Citations for Recombinant Mouse CCL17/TARC Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
    Authors: CH Pai, SR Lin, CH Liu, SY Pan, H Hsu, YT Chen, CT Yen, IS Yu, HL Wu, SL Lin, SW Lin
    Sci Rep, 2020-10-08;10(1):16772.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. IL-23 in arthritic and inflammatory pain development in mice
    Authors: KM Lee, Z Zhang, A Achuthan, AJ Fleetwood, JE Smith, JA Hamilton, AD Cook
    Arthritis Res. Ther., 2020-05-29;22(1):123.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  3. Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism
    Authors: S Usuki, N Tamura, T Tamura, S Higashiyam, K Tanji, S Mitsutake, A Inoue, J Aoki, K Mukai, Y Igarashi
    Biochem Biophys Rep, 2019-01-03;17(0):132-138.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17
    Authors: AD Cook, MC Lee, R Saleh, HW Khiew, AD Christense, A Achuthan, AJ Fleetwood, DC Lacey, JE Smith, I Förster, JA Hamilton
    JCI Insight, 2018-03-22;3(6):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  5. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation
    J Clin Invest, 2016-08-15;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  6. IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin
    Authors: SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes
    J. Immunol, 2016-02-05;196(6):2514-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.
    Authors: Loebbermann, Jens, Durant, Lydia, Thornton, Hannah, Johansson, Cecilia, Openshaw, Peter J
    Proc Natl Acad Sci U S A, 2013-02-04;110(8):2987-92.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  8. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.
    Authors: Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Forster I, Kurts C
    Nat. Immunol., 2010-02-28;11(4):313-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway.
    Authors: Kearley J, Buckland KF, Mathie SA, Lloyd CM
    Am. J. Respir. Crit. Care Med., 2009-01-29;179(9):772-81.
    Applications: ELISA (Standard)
  10. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
    Authors: Kearley J, Robinson DS, Lloyd CM
    J. Allergy Clin. Immunol., 2008-07-30;122(3):617-24.e6.
    Applications: ELISA (Standard)
  11. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.
    Authors: Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT
    J. Immunol., 2007-10-01;179(7):4661-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli.
    Authors: Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K
    Eur. J. Immunol., 2006-08-01;36(8):2116-27.
    Species: Mouse
    Sample Types: N/A, Whole Cells
    Applications: Bioassay, Western Blot
  13. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.
    Authors: Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA
    Blood, 2004-05-13;104(5):1404-10.
    Applications: ELISA (Standard)

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Recombinant Mouse CCL17/TARC Protein
By Anonymous on 01/05/2018
Application: Immunoassay Standard
Immunoassay Standard Recombinant Mouse CCL17/TARC Protein 529-TR