Home / Leptin/OB / Recombinant Mouse Leptin Protein, CF

Recombinant Mouse Leptin Protein, CF

Catalog #: 498-OB
91 Citations 4 Reviews Datasheet
Catalog # Availability Size / Price Qty
498-OB-01M
498-OB-05M
R&D Systems Recombinant Proteins and Enzymes
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Citations (91)
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Reviews (4)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse Leptin Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human Leptin R. The ED50 for this effect is 0.075-0.45 ng/mL.
Source
E. coli-derived mouse Leptin/OB protein
Val22-Cys167, with an N-terminal Met
Accession #
Q544U0
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
16 kDa

Product Datasheets

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498-OB

Product Datasheet

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

498-OB

Formulation Lyophilized from a 0.2 μm filtered solution in Tris-HCl and NaCl.
Reconstitution Reconstitute at 1 mg/mL in sterile 20 mM Tris-HCI, pH 8.0.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Leptin/OB

Leptin is a protein product of the mouse obese gene. Mice with mutations in the obese gene that block the synthesis of Leptin have been found to be obese and diabetic and to have reduced activity, metabolism and body temperature. cDNA clones encoding Leptin have been isolated from human, simian, mouse and rat cells. Mouse Leptin shares approximately 96% and 84% sequence identity with the rat and human protein, respectively. Mouse Leptin cDNA encodes a 167 amino acid residue protein with a 21 amino acid residue signal sequence that is cleaved to yield the 146 amino acid residue mature protein. The expression of Leptin mRNA has been shown to be restricted to adipose tissue.

A high-affinity receptor for Leptin (OB-R) with homology to gp130 and the G-CSF receptor has been cloned. OB-R mRNA has been shown to be expressed in the choroid plexus and in the hypothalamus. OB-R has also been identified as an isoform of B219, a sequence that is expressed in at least four isoforms in very primitive hematopoietic cell populations and in a variety of lymphohematopoietic cell lines (1-3). The possible roles of Leptin in body weight regulation, hematopoiesis and reproduction are being investigated.

References
  1. Considine, R. and J. Caro (1996) Clinical Chemistry 42:843.
  2. Tartaglia, L.A. et al. (1995) Cell 83:1263.
  3. Cioffi, J.A. et al. (1996) Nature Medicine 2:585.
Entrez Gene IDs
3952 (Human); 16846 (Mouse); 25608 (Rat)
Alternate Names
FLJ94114; LEP; leptin (murine obesity homolog); leptin (obesity homolog, mouse); Leptin; OB; Obese protein; obese, mouse, homolog of; Obesity factor; OBOBS

Citations for Recombinant Mouse Leptin Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

91 Citations: Showing 1 - 10
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  1. Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues
    Authors: Zhang, X;Majumdar, A;Kim, C;Kleiboeker, B;Magee, KL;Learman, BS;Thomas, SA;Lodhi, IJ;MacDougald, OA;Scheller, EL;
    bioRxiv : the preprint server for biology
    Species: Transgenic Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  2. AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation
    Authors: Qiu, S;Wu, Q;Wang, H;Liu, D;Chen, C;Zhu, Z;Zheng, H;Yang, G;Li, L;Yang, M;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells, In Vivo
    Applications: Bioassay, In vivo assay
  3. SEL1L-HRD1 ER-associated degradation regulates leptin receptor maturation and signaling in POMC neurons in diet-induced obesity
    Authors: Mao, H;Kim, GH;Qi, L;
    Research square
    Species: Mouse
    Sample Types:
  4. Designer Fat Cells: Adipogenic Differentiation of CRISPR-Cas9 Genome-Engineered Induced Pluripotent Stem Cells
    Authors: Ely, EV;Kapinski, AT;Paradi, SG;Tang, R;Guilak, F;Collins, KH;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice
    Authors: Milà-Guasch, M;Ramírez, S;Llana, SR;Fos-Domènech, J;Dropmann, LM;Pozo, M;Eyre, E;Gómez-Valadés, AG;Obri, A;Haddad-Tóvolli, R;Claret, M;
    PLoS biology
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  6. Neural stem cell self-renewal stimulation by store-operated calcium entries in adult mouse area postrema: influence of leptin
    Authors: Ben Dhaou, C;Terrié, E;Déliot, N;Harnois, T;Cousin, L;Arnault, P;Constantin, B;Moyse, E;Coronas, V;
    Frontiers in cellular neuroscience
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages
    Authors: K Takahashi, T Yamada, S Hosaka, K Kaneko, Y Asai, Y Munakata, J Seike, T Horiuchi, S Kodama, T Izumi, S Sawada, K Hoshikawa, J Inoue, A Masamune, Y Ueno, J Imai, H Katagiri
    Cell Reports, 2023-04-27;0(0):112415.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  8. The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
    Authors: D Chamseddin, SA Mahmud, AK Westfall, TA Castoe, RE Berg, MW Pellegrino
    Cell Reports, 2022-12-13;41(11):111789.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  9. Ras drives malignancy through stem cell crosstalk with the microenvironment
    Authors: S Yuan, KS Stewart, Y Yang, MD Abdusselam, SM Parigi, TY Feinberg, K Tumaneng, H Yang, JM Levorse, L Polak, D Ng, E Fuchs
    Nature, 2022-11-30;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  10. Hypothalamic TTF-1 orchestrates the sensitivity of leptin
    Authors: BS Park, D Kang, KK Kim, B Jeong, TH Lee, JW Park, S Kimura, JY Yeh, GS Roh, CJ Lee, S Yang, S Yang, JG Kim, BJ Lee
    Molecular Metabolism, 2022-11-11;0(0):101636.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  11. Leptin enhances social motivation and reverses chronic unpredictable stress-induced social anhedonia during adolescence
    Authors: Y Lei, D Wang, Y Bai, J Nougaisse, NL Weintraub, M Guo, XY Lu
    Molecular Psychiatry, 2022-09-22;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  12. Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life
    Authors: J Selle, K Dinger, V Jentgen, D Zanetti, J Will, T Georgomano, C Vohlen, R Wilke, B Kojonazaro, O Klymenko, J Mohr, S V Koningsb, CJ Rhodes, A Ulrich, D Hirani, T Nestler, M Odenthal, E Mahabir, S Nayakanti, S Dabral, T Wunderlich, J Priest, W Seeger, J Dötsch, SS Pullamsett, MA Alejandre
    Nature Communications, 2022-07-27;13(1):4352.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Hypothyroidism confers tolerance to cerebral malaria
    Authors: D Rodriguez-, Á Sánchez, S Pérez-Bena, C Contreras-, A Montero-Pe, M Toledo-Cas, M Gutiérrez-, R Rodrigues-, C Folgueira, AM Briones, G Sabio, I Monedero-C, I Chávez-Coi, D Castejón, E Fernández-, J Regadera, JM Bautista, A Aranda, S Alemany
    Science Advances, 2022-04-06;8(14):eabj7110.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  14. Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling
    Authors: PP van Krieke, TS Odermatt, M Borsigova, M Blüher, S Wueest, D Konrad
    Molecular Metabolism, 2021-09-20;0(0):101341.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Milk Osteopontin for Gut, Immunity and Brain Development in Preterm Pigs
    Authors: K Aasmul-Ols, NL Henriksen, DN Nguyen, AB Heckmann, T Thymann, PT Sangild, SB Bering
    Nutrients, 2021-07-31;13(8):.
    Species: Porcine
    Sample Types: Plasma
  16. Leptin Improves Parameters of Brown Adipose Tissue Thermogenesis in Lipodystrophic Mice
    Authors: A Hoffmann, T Ebert, MK Hankir, G Flehmig, N Klöting, B Jessnitzer, U Lössner, M Stumvoll, M Blüher, M Fasshauer, A Tönjes, K Miehle, S Kralisch
    Nutrients, 2021-07-22;13(8):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  17. A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity
    Authors: CE Geisler, S Ghimire, SM Bruggink, KE Miller, SN Weninger, JM Kronenfeld, J Yoshino, S Klein, FA Duca, BJ Renquist
    Cell Reports, 2021-06-29;35(13):109301.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  18. BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet
    Authors: D Díaz-Catal, G Alcarraz-V, C Castaño, S de Pablo, J Rodríguez-, A Fernández-, M Vallejo, S Ramírez, M Claret, M Parrizas, A Novials, JM Servitja
    Molecular Metabolism, 2021-05-17;0(0):101251.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  19. A synergy of estradiol with leptin modulates the long non-coding RNA NEAT1/ mmu-miR-204-5p/IGF1 axis in the uterus of high-fat-diet-induced obese ovariectomized mice
    Authors: A Shetty, PS Suresh
    The Journal of steroid biochemistry and molecular biology, 2021-02-12;209(0):105843.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  20. Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade
    Authors: C Li, F Meng, Y Lei, J Liu, J Liu, J Zhang, F Liu, C Liu, M Guo, XY Lu
    Mol Psychiatry, 2020-10-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  21. Effect of Lactobacillus rhamnosus GG on Energy Metabolism, Leptin Resistance, and Gut Microbiota in Mice with Diet-Induced Obesity
    Authors: YC Cheng, JR Liu
    Nutrients, 2020-08-24;12(9):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay, In Vivo
  22. Chronic Gq signaling in AgRP neurons does not cause obesity
    Authors: SN Ewbank, CA Campos, JY Chen, AJ Bowen, SL Padilla, JL Dempsey, JY Cui, RD Palmiter
    Proc. Natl. Acad. Sci. U.S.A., 2020-08-06;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  23. Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance
    Authors: S Hosaka, T Yamada, K Takahashi, T Dan, K Kaneko, S Kodama, Y Asai, Y Munakata, A Endo, H Sugawara, Y Kawana, J Yamamoto, T Izumi, S Sawada, J Imai, T Miyata, H Katagiri
    Front Pharmacol, 2020-06-24;11(0):943.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  24. Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation
    Authors: S Jin, KK Kim, BS Park, DH Kim, B Jeong, D Kang, TH Lee, JW Park, JG Kim, BJ Lee
    J Neuroinflammation, 2020-06-19;17(1):195.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  25. Neuroprotective effects of leptin on cerebral ischemia through JAK2/STAT3/PGC-1-mediated mitochondrial function modulation
    Authors: W Zhang, Y Jin, D Wang, J Cui
    Brain Res. Bull., 2020-01-11;156(0):118-130.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  26. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
    Authors: V Frodermann, D Rohde, G Courties, N Severe, MJ Schloss, H Amatullah, CS McAlpine, S Cremer, FF Hoyer, F Ji, ID van Koever, F Herisson, L Honold, GS Masson, S Zhang, J Grune, Y Iwamoto, SP Schmidt, GR Wojtkiewic, IH Lee, K Gustafsson, G Pasterkamp, SCA de Jager, RI Sadreyev, J MacFadyen, P Libby, P Ridker, DT Scadden, K Naxerova, KL Jeffrey, FK Swirski, M Nahrendorf
    Nat. Med., 2019-11-07;25(11):1761-1771.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  27. Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance
    Authors: DJ Torres, MW Pitts, AC Hashimoto, MJ Berry
    Nutrients, 2019-07-23;11(7):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  28. Gs? deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling
    Authors: M Chen, EA Wilson, Z Cui, H Sun, YB Shrestha, B Podyma, CH Le, B Naglieri, K Pacak, O Gavrilova, LS Weinstein
    Mol Metab, 2019-04-12;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  29. Adipocyte OGT governs diet-induced hyperphagia and obesity
    Authors: MD Li, NB Vera, Y Yang, B Zhang, W Ni, E Ziso-Qejva, S Ding, K Zhang, R Yin, S Wang, X Zhou, EX Fang, T Xu, DM Erion, X Yang
    Nat Commun, 2018-11-30;9(1):5103.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  30. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
    Authors: Z Wang, EG Aguilar, JI Luna, C Dunai, LT Khuat, CT Le, A Mirsoian, CM Minnar, KM Stoffel, IR Sturgill, SK Grossenbac, SS Withers, RB Rebhun, DJ Hartigan-O, G Méndez-Lag, AF Tarantal, RR Isseroff, TS Griffith, KA Schalper, A Merleev, A Saha, E Maverakis, K Kelly, R Aljumaily, S Ibrahimi, S Mukherjee, M Machiorlat, SK Vesely, DL Longo, BR Blazar, RJ Canter, WJ Murphy, AM Monjazeb
    Nat. Med., 2018-11-12;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  31. Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation
    Authors: CH Lee, HJ Kim, YS Lee, GM Kang, HS Lim, SH Lee, DK Song, O Kwon, I Hwang, M Son, K Byun, YH Sung, S Kim, JB Kim, EY Choi, YB Kim, K Kim, MN Kweon, JW Sohn, MS Kim
    Cell Rep, 2018-10-23;25(4):934-946.e5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  32. Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
    Authors: MA Smith, L Katsouri, S Virtue, AI Choudhury, A Vidal-Puig, MLJ Ashford, DJ Withers
    Cell Rep, 2018-10-09;25(2):278-287.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice
    Authors: KA Philbrick, AJ Branscum, CP Wong, RT Turner, UT Iwaniec
    Sci Rep, 2018-10-04;8(1):14790.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation
    Authors: YH Lee, HC Hsu, PC Kao, YJ Shiao, SH Yeh, FS Shie, SM Hsu, CW Yeh, HK Liu, SB Yang, HJ Tsay
    Int J Mol Sci, 2018-08-08;19(8):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  35. Neuronatin regulates pancreatic ? cell insulin content and secretion
    Authors: SJ Millership, G da Silva X, AI Choudhury, S Bertazzo, P Chabosseau, SM Pedroni, EE Irvine, A Montoya, P Faull, WR Taylor, J Kerr-Conte, F Pattou, J Ferrer, M Christian, RM John, M Latreille, M Liu, GA Rutter, J Scott, DJ Withers
    J. Clin. Invest., 2018-07-09;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  36. Leptin/Osteopontin Axis Regulated Type 2T Helper Cell Response in Allergic Rhinitis with Obesity
    Authors: Q Zeng, X Luo, M Han, W Liu, H Li
    EBioMedicine, 2018-06-07;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  37. Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice
    Authors: M Kleinert, P Kotzbeck, T Altendorfe, T Birngruber, MH Tschöp, C Clemmensen
    Mol Metab, 2018-04-27;13(0):77-82.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  38. HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain
    Authors: DJ Rawle, D Li, JE Swedberg, L Wang, DC Soares, D Harrich
    MBio, 2018-03-27;9(2):.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: Bioassay
  39. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity
    Authors: GH Kim, G Shi, DR Somlo, L Haataja, S Song, Q Long, EA Nillni, MJ Low, P Arvan, MG Myers, L Qi
    J. Clin. Invest., 2018-02-19;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  40. Loss of pericyte smoothened activity in mice with genetic deficiency of leptin
    Authors: G Xie, M Swiderska-, ML Jewell, MV Machado, GA Michelotti, RT Premont, AM Diehl
    BMC Cell Biol., 2017-04-20;18(1):20.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  41. Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity
    Authors: D Yuan, X Yi, Y Zhao, CD Poon, KM Bullock, KM Hansen, TS Salameh, SA Farr, WA Banks, AV Kabanov
    J Control Release, 2017-03-24;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  42. MC4R-dependent suppression of appetite by bone-derived lipocalin 2
    Authors: I Mosialou, S Shikhel, JM Liu, A Maurizi, N Luo, Z He, Y Huang, H Zong, RA Friedman, J Barasch, P Lanzano, L Deng, RL Leibel, M Rubin, T Nicholas, W Chung, LM Zeltser, KW Williams, JE Pessin, S Kousteni
    Nature, 2017-03-08;543(7645):385-390.
    Species: Human
    Sample Types: Whole Cells
    Applications: Control
  43. Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity
    Authors: GA Raciti, R Spinelli, A Desiderio, M Longo, L Parrillo, C Nigro, V D'Esposito, P Mirra, F Fiory, V Pilone, P Forestieri, P Formisano, I Pastan, C Miele, F Beguinot
    Sci Rep, 2017-03-07;7(0):43526.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. An ATF4/ATG5 Signaling in Hypothalamic POMC Neurons Regulates Fat Mass via Affecting Energy Expenditure
    Authors: Y Xiao, Y Deng, F Yuan, T Xia, H Liu, Z Li, Z Liu, H Ying, Y Liu, Q Zhai, S Chen, F Guo
    Diabetes, 2017-02-17;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  45. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation
    Nat. Med, 2016-12-12;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  46. High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism
    Authors: Rafael Leite Morais
    Am. J. Physiol. Heart Circ. Physiol, 2016-12-09;0(0):ajpheart.0048.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  47. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
    Eur J Immunol, 2016-06-13;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  48. Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus
    Sci Rep, 2016-05-05;6(0):25399.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  49. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
    Authors: Kim, Min Soo, Yan, Jingqi, Wu, Wenhe, Zhang, Guo, Zhang, Yalin, Cai, Dongshen
    Nat Immunol, 2015-04-06;16(5):525-33.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  50. Leptin promotes wound healing in the skin.
    Authors: Tadokoro, Susumu, Ide, Shinji, Tokuyama, Reiko, Umeki, Hirochik, Tatehara, Seiko, Kataoka, Shiki, Satomura, Kazuhito
    PLoS ONE, 2015-03-23;10(3):e0121242.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  51. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression.
    Authors: Mejia P, Trevino-Villarreal J, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh M, Mitchell J
    Nat Commun, 2015-01-30;6(0):6050.
    Species: Mouse
    Sample Types: Whole Organism
    Applications: In Vivo
  52. Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice.
    Authors: Tillman, Erik J, Morgan, Donald A, Rahmouni, Kamal, Swoap, Steven J
    PLoS ONE, 2014-09-11;9(9):e107206.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  53. Intranasal administration as a route for drug delivery to the brain: evidence for a unique pathway for albumin.
    Authors: Falcone, Joseph A, Salameh, Therese, Yi, Xiang, Cordy, Benjamin, Mortell, William, Kabanov, Alexande, Banks, William
    J Pharmacol Exp Ther, 2014-07-15;351(1):54-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  54. Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
    Authors: Yoshino S, Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano-Toki A, Kakizaki S, Okada S, Shimizu H, Ozawa A, Tuchiya T, Ikota H, Nakazato Y, Mori M, Matozaki T, Sasaki T, Kitamura T, Mori M
    Endocrinology, 2014-07-08;155(9):3459-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.
    Authors: Briggs, Dana I, Lockie, Sarah H, Benzler, Jonas, Wu, Qunli, Stark, Romana, Reichenbach, Alex, Hoy, Andrew J, Lemus, Moyra B, Coleman, Harold A, Parkington, Helena C, Tups, Alex, Andrews, Zane B
    Endocrinology, 2014-04-17;155(7):2411-22.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  56. Kinetics of leptin binding to the Q223R leptin receptor.
    Authors: Verkerke H, Naylor C, Zabeau L, Tavernier J, Petri W, Marie C
    PLoS ONE, 2014-04-17;9(4):e94843.
    Species: Human
    Sample Types: Antibody
    Applications: Surface Plasmon Resonance
  57. Leptin-promoted cilia assembly is critical for normal energy balance.
    Authors: Han Y, Kang G, Byun K, Ko H, Kim J, Shin M, Kim H, Gil S, Yu J, Lee B, Kim M
    J Clin Invest, 2014-03-25;124(5):2193-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  58. Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process.
    Authors: Yuan, Miao, Huang, Guizhen, Li, Jun, Zhang, Jie, Li, Fei, Li, Kai, Gao, Bo, Zeng, Li, Shan, Wei, Lin, Ping, Huang, Lugang
    Reprod Biol Endocrinol, 2014-02-06;12(0):15.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  59. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress.
    Authors: Hosoi, Toru, Yamaguchi, Rie, Noji, Kikuko, Matsuo, Suguru, Baba, Sachiko, Toyoda, Keisuke, Suezawa, Takahiro, Kayano, Takaaki, Tanaka, Shinpei, Ozawa, Koichiro
    EMBO Mol Med, 2014-01-13;6(3):335-46.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  60. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.
    Authors: Moraes-Vieira P, Larocca R, Bassi E, Peron J, Andrade-Oliveira V, Wasinski F, Araujo R, Thornley T, Quintana F, Basso A, Strom T, Camara N
    Eur J Immunol, 2014-01-13;44(3):794-806.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Fas lpr mice.
    Authors: Fujita Y, Fujii T, Mimori T, Sato T, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Kawanami T, Tanaka M, Masaki Y, Fukushima T, Okazaki T, Umehara H
    J Immunol, 2014-01-03;192(3):979-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.
    Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N
    Circ Res, 2013-09-30;113(12):1331-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling.
    Authors: Wang, Lingdi, Wang, Xiao, Li, Zhenghu, Xia, Tingting, Zhu, Lu, Liu, Bin, Zhang, Yongxian, Xiao, Fei, Pan, Yi, Liu, Yong, Guo, Feifan, Chen, Yan
    Endocrinology, 2013-09-13;154(12):4525-35.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  64. BBS mutations modify phenotypic expression of CEP290-related ciliopathies.
    Authors: Zhang, Yan, Seo, Seongjin, Bhattarai, Sajag, Bugge, Kevin, Searby, Charles, Zhang, Qihong, Drack, Arlene V, Stone, Edwin M, Sheffield, Val C
    Hum Mol Genet, 2013-08-13;23(1):40-51.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. Carbon monoxide-releasing molecules reverse leptin resistance induced by endoplasmic reticulum stress.
    Authors: Zheng M, Zhang Q, Joe Y, Kim S, Uddin M, Rhew H, Kim T, Ryter S, Chung H
    Am J Physiol Endocrinol Metab, 2013-02-12;304(7):E780-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  66. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
    Authors: Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Goransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegovic M
    PLoS ONE, 2012-02-28;7(2):e32700.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  67. Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice.
    Authors: Blouet C, Schwartz GJ
    J. Neurosci., 2011-04-20;31(16):6019-27.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms.
    Authors: Li X, Wu X, Camacho R
    PLoS ONE, 2011-02-17;6(2):e17058.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  69. Leptin exacerbates sepsis-mediated morbidity and mortality.
    Authors: Shapiro NI, Khankin EV, van Meurs M
    J. Immunol., 2010-06-02;185(1):517-24.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  70. Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors.
    Authors: Kim KS, Yoon YR, Lee HJ, Yoon S, Kim SY, Shin SW, An JJ, Kim MS, Choi SY, Sun W, Baik JH
    J. Biol. Chem., 2010-01-15;285(12):8905-17.
    Species: Human, Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  71. Functional role of c-Jun-N-terminal kinase in feeding regulation.
    Authors: Unger EK, Piper ML, Olofsson LE, Xu AW
    Endocrinology, 2009-12-18;151(2):671-82.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
    Authors: Pini M, Fantuzzi G
    J. Leukoc. Biol., 2009-09-10;87(1):51-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  73. Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution.
    Authors: Gruver AL, Ventevogel MS, Sempowski GD
    J. Endocrinol., 2009-07-08;203(1):75-85.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  74. Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis.
    Authors: Neels JG, Badeanlou L, Hester KD, Samad F
    J. Biol. Chem., 2009-06-03;284(31):20692-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  75. Leptin enhances CC-chemokine ligand expression in cultured murine macrophage.
    Authors: Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S
    Biochem. Biophys. Res. Commun., 2009-05-03;384(3):311-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice.
    Authors: Narvekar P, Berriel Diaz M, Krones-Herzig A, Hardeland U, Strzoda D, Stohr S, Frohme M, Herzig S
    Diabetes, 2009-02-02;58(5):1040-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  77. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.
    Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L
    Lab. Invest., 2008-11-10;89(2):222-30.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  78. Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.
    Authors: Fenton JI, Birmingham JM, Hursting SD, Hord NG
    Int. J. Cancer, 2008-06-01;122(11):2437-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Adipose tissue gene expression profiles in ob/ob mice treated with leptin.
    Authors: Zhang W, Della-Fera MA, Hartzell DL, Hausman D, Baile CA
    Life Sci., 2008-05-10;83(1):35-42.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  80. Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue.
    Authors: Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C
    Endocrinology, 2008-02-14;149(5):2361-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  81. FXR-deficiency confers increased susceptibility to torpor.
    Authors: Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B
    FEBS Lett., 2007-10-12;581(27):5191-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  82. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation.
    Authors: Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K
    Am. J. Physiol. Heart Circ. Physiol., 2007-01-12;292(5):H2387-96.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  83. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding.
    Authors: Xu AW, Ste-Marie L, Kaelin CB, Barsh GS
    Endocrinology, 2006-10-05;148(1):72-80.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  84. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity.
    Authors: Raju SV, Zheng M, Schuleri KH, Phan AC, Bedja D, Saraiva RM, Yiginer O, Vandegaer K, Gabrielson KL, O&amp;apos;Donnell CP, Berkowitz DE, Barouch LA, Hare JM
    Proc. Natl. Acad. Sci. U.S.A., 2006-03-06;103(11):4222-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  85. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis.
    Authors: De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G
    J. Clin. Invest., 2006-01-12;116(2):447-55.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  86. BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry.
    Authors: Mistrik P, Moreau F, Allen JM
    Anal. Biochem., 2004-04-15;327(2):271-7.
    Species: Human, Mouse
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  87. Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice.
    Authors: Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, Schrier R
    J. Am. Soc. Nephrol., 2004-03-01;15(3):645-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  88. The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.
    Authors: Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R
    Endocrinology, 2002-11-01;143(11):4304-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  89. Leptin accelerates autoimmune diabetes in female NOD mice.
    Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A
    Diabetes, 2002-05-01;51(5):1356-61.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  90. Interferon-alpha suppresses leptin levels: studies in interferon-alpha treated patients with hepatitis C virus infection and murine adipocytes.
    Authors: Kaser S, Kaser A, Vogel W, Patsch JR, Tilg H
    Eur. Cytokine Netw., 2002-04-01;13(2):225-9.
    Applications: ELISA (Standard)
  91. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice.
    Authors: Lin S, Thomas TC, Storlien LH
    Int. J. Obes. Relat. Metab. Disord., 2000-05-01;24(5):639-46.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

FAQs

  1. Can I reconstitute this in PBS?

    • We strongly recommend reconstituting this protein in 20 mM Tris-HCI, pH 8.0 as indicated on the product insert. This is the most stable buffer we have found for reconstitution and subsequent storage of this protein.

View all Proteins and Enzyme FAQs

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Recombinant Mouse Leptin Protein, CF
By Dominique Ameroso on 04/09/2019
Application: In vivo study
Reason for Rating: Administered 3 ug/g to B6 mice 2x a day for two days prior to tissue harvesting to examine protein expression. This lead to a significant decrease in body weight in leptin compared to vehicle treated mice which confirms the leptins efficiency.
Recombinant Mouse Leptin Protein, CF
By Anonymous on 04/03/2019
Application: In vivo study
In vivo study Recombinant Mouse Leptin Protein, CF 498-OB
Recombinant Mouse Leptin Protein, CF
By Anonymous on 09/01/2016
Application: In vitro bioactivity in cell culture
Recombinant Mouse Leptin Protein, CF
By Anonymous on 05/17/2016
Application: Detection of leptin receptors in cells