Zonisamide
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Description: Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)
Alternative Names: AD 810,CI 912
Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
Purity: ≥99%
Biological Activity
Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.Technical Data
M.Wt:
212.22
Formula:
C8H8N2O3S
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
68291-97-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Zonisamide: a new antiepileptic drug.
Sobieszek et al.
Pol.J.Pharmacol., 2003;55:683 -
Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
Gluck et al.
J.Neural Transm., 2004;111:713 -
Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Huang et al.
J.Pharmacol.Exp.Ther., 2007;321:98 -
In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats.
Tokumaru et al.
Neurochem.Res., 2000;25:1107
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