YM 155
Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Purity: ≥98%
Biological Activity
YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines.
Iwasa et al.
Clin.Cancer Res., 2008;14:6496 -
Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway.
Premkumar et al.
J.Pharmacol.Exp.Ther., 2013;346:201
Product Datasheets
Citations for YM 155
The citations listed below are publications that use Tocris products. Selected citations for YM 155 include:
2 Citations: Showing 1 - 2
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SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model.
Authors: Serafini Et al.
Sci.Signal. 2023;16:eade4984
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Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Authors: Eric Et al.
Dev Cell 2019;49:393-408.e7
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