YK 4-279

Catalog #: 4067 Datasheet

Catalog #	Availability	Size / Price	Qty
4067/10
4067/50

YK 4-279 | CAS No. 1037184-44-3 | DNA, RNA and Protein Synthesis Inhibitors

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Description: Inhibitor of RNA helicase A (RHA)

Chemical Name: 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.

Technical Data

M.Wt:

366.2

Formula:

C₁₇H₁₃Cl₂NO₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

1037184-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma.
Erkizan et al.
Nat.Med., 2009;15:750

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