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WDR5 0103

Catalog #: 5323 Datasheet
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WDR5 0103 | CAS No. 890190-22-4 | Additional Lysine Methyltransferase Compounds
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Description: WDR5 antagonist

Chemical Name: 3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester

Purity: ≥99%

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Biological Activity

WDR5 0103 is a WD repeat-containing protein 5 (WDR5) antagonist (Kd = 450 nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.

Technical Data

M.Wt:
383.44
Formula:
C21H25N3O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
890190-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
    Senisterra et al.
    Biochem.J., 2013;449:151

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