WAY 213613
Chemical Name: N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine
Purity: ≥99%
Biological Activity
WAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Another study has found WAY 213613 has 12 - 26-fold selectivity for EAAT2 over EAAT1, EAAT3 and EAAT4 (IC50 values are 0.071, 0.86, 1.5 and 1.9 nM for EAAT2, EAAT1, EAAT4 and EAAT3, respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2.
Dunlop et al.
Mol.Pharmacol., 2005;68:974 -
Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.
Beart and Shea
Br.J.Pharmacol., 2007;150:5
Product Datasheets
Citations for WAY 213613
The citations listed below are publications that use Tocris products. Selected citations for WAY 213613 include:
3 Citations: Showing 1 - 3
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Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
Authors: Falcucci Et al.
ACS Chem Neurosci 2019;10:3437
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Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Authors: Brancaccio Et al.
Neuron 2017;93:1420
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Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis.
Authors: Dumont Et al.
Evid Based Complement Alternat Med 2014;9:e97649
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