W146
Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
Purity: ≥98%
Biological Activity
W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Sanna et al.
Nat.Chem.Biol., 2006;8:434 -
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions.
Gonzalez-Cabrera et al.
Mol.Pharmacol., 2008;74:1308
Product Datasheets
Citations for W146
The citations listed below are publications that use Tocris products. Selected citations for W146 include:
8 Citations: Showing 1 - 8
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Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux.
Authors: Chen Et al.
Front Immunol 2023;14:1090202
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Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
Authors: Richard M Et al.
Immunity 2022;55:254-271.e7
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Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Authors: Lucia Et al.
Arterioscler Thromb Vasc Biol 2021;41:e468-e479
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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Authors: Huilan Et al.
Proc Natl Acad Sci U S A 2021;118
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Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
Authors: Schuhmann Et al.
Mol Cell Biol 2015;16:29454
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Fingolimod induces neuroprotective factors in human astrocytes.
Authors: Hoffmann Et al.
J Neuroinflammation 2015;12:184
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Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
Authors: Beckham Et al.
PLoS One 2013;8:e76593
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Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Authors: Beckham Et al.
Oncogenesis 2013;2:e49
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