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VU 0364739 hydrochloride

Catalog #: 4171
10 Citations Datasheet
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VU 0364739 hydrochloride | CAS No. 1244640-48-9 | Phospholipase Inhibitors
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Description: Potent and selective PLD2 inhibitor

Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide

Purity: ≥98%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).

Technical Data

M.Wt:
482.98
Formula:
C26H27FN4O2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1244640-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits
    B Krishnan, R Kayed, G Taglialate
    Alzheimers Dement (N Y), 2018;4(0):89-102.
  2. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
    Lavieri et al.
    J.Med.Chem., 2010;53:6709

Product Datasheets

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Citations for VU 0364739 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:

10 Citations: Showing 1 - 10

  1. Parkin coordinates mitochondrial lipid remodeling to execute mitophagy.
    Authors: Xiao-Fan Et al.
    EMBO Rep  2022;23:e55191
  2. Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus.
    Authors: Tove Irene Et al.
    Cell Mol Life Sci  2021;78:985-1009
  3. Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation.
    Authors: Bich Et al.
    Sci Rep  2018;8:6283
  4. An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets.
    Authors: Lu Et al.
    J Clin Med  2018;7
  5. Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits.
    Authors: Krishnan Et al.
    Alzheimer Dement (N Y)  2018;4:89
  6. Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.
    Authors: Chelakkot Et al.
    Sci Rep  2017;7:1573
  7. PLD2 regulates microtubule stability and spindle migration in mouse oocytes during meiotic division.
    Authors: Liu Et al.
    PeerJ  2017;5:e3295
  8. Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.
    Authors: Jiang Et al.
    J Biol Chem.  2016;291:20729
  9. Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment.
    Authors: Martínez-Martínez Et al.
    PLoS One  2014;9:e111685
  10. The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.
    Authors: Basiouni Et al.
    Autophagy  2013;14:9005

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