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Viomycin

Catalog #: 3787
5 Citations Datasheet
Catalog # Availability Size / Price Qty
3787/10
Viomycin | Antibiotics
1 Image
Description: Antibiotic; inhibits bacterial DNA synthesis

Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Technical Data

M.Wt:
881.85
Formula:
C25H43N13O10.2H2SO4
Solubility:
Soluble to 75 mM in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. The allosteric three-site model for the ribosomal elongation cycle.
    Hausner et al.
    J.Biol.Chem., 1988;263:13103
  2. Modulation of RNA function by aminoglycoside antibiotics.
    Schroeder et al.
    EMBO J., 2000;19:1
  3. The antibiotic vio. traps the ribosome in an intermediate state of translocation.
    Ermolenko et al.
    Nat.Struct.Mol.Biol., 2007;14:493

Product Datasheets

Citations for Viomycin

The citations listed below are publications that use Tocris products. Selected citations for Viomycin include:

5 Citations: Showing 1 - 5

  1. Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer.
    Authors: Matilde E Et al.
    Mol Cell Proteomics  2019;18:231-244
  2. Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer.
    Authors: Abad Et al.
    Mol Cell Proteomics  2018;
  3. Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.
    Authors: Freihofer Et al.
    RNA  2016;22:1836
  4. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.
    Authors: Samokhvalov Et al.
    PLoS One  2015;232:44105
  5. Molecular basis for the selectivity of antituberculosis compounds capreo. and vio.
    Authors: Akbergenov Et al.
    Antimicrob Agents Chemother  2011;55:4712

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