VH 032 amide-PEG4-amine

Catalog #: 6464 1 Review Datasheet

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VH 032 amide-PEG4-amine | CAS No. 2446474-04-8 | Degrader Building Blocks

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Description: VHL ligand with PEG linker and terminal amine for onward chemistry

Alternative Names: (S,R,S)-AHPC-PEG4-NH₂

Chemical Name: (2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity: ≥95%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VH 032 amide-PEG4-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 2

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:

736.75

Formula:

C₃₂H₄₉N₅O₈S.2HCl

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

2446474-04-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Selective small molecule induced degradation of the BET bromodomain protein BRD4.
Zengerle et al.
ACS Chem.Biol., 2015;10:1770
Waste disposal-An attractive strategy for cancer therapy.
Salami et al.
Science, 2017;355:1163
Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds.
Chan et al.
J.Med.Chem., 2018;61:504

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Preparation of protacs

By Sandipan Roy Chowdhury on 05/19/2020

Species: cells

to make protacs

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