Venlafaxine hydrochloride

Catalog #: 2917
3 Citations Datasheet

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2917/10
2917/50

Venlafaxine hydrochloride | CAS No. 99300-78-4 | 5-HT Transporter Inhibitors

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Description: 5-HT and NA reuptake inhibitor (SNRI)

Alternative Names: Wy 45030

Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

Purity: ≥99%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (K_i values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Technical Data

M.Wt:

313.86

Formula:

C₁₇H₂₇NO₂.HCl

Solubility:

Soluble to 100 mM in water and to 50 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

99300-78-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats.
Magalas et al.
Eur.J.Pharmacol., 2005;528:103
A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters.
Gould et al.
Biol.Psychiatry, 2006;59:408

Product Datasheets

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SDS

Citations for Venlafaxine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:

3 Citations: Showing 1 - 3

Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy.
Authors: Stuart Et al.
Proc Natl Acad Sci U S A 2015;40:2165
Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
Authors: Yuen Et al.
J Biol Chem 2014;289:25177
A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
Neuropsychopharmacology 2013;38:1625

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