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Vandetanib

Catalog #: 7497 Datasheet
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7497/10
7497/50
Vandetanib | CAS No. 443913-73-3 | VEGF Receptor Inhibitors
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Description: Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity

Chemical Name: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine

Purity: ≥98%

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Biological Activity

Vandetanib is a potent VEGFR-2 inhibitor (IC50 = 0.04 μM), and inhibitor of EGFR (IC50 = 0.5 μM). Vandetanib potently inhibits (IC50 = 100 nM) RET oncoprotein activity in human thyroid cancer. Vandetanib displays anti-angiogenic properties in human nasopharyngeal carcinoma in mice model. Vandetanib is orally available and effective in vivo.

Technical Data

M.Wt:
475.36
Formula:
C22H24BrFN4O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
443913-73-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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