URB 597
Chemical Name: Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
Purity: ≥99%
Biological Activity
URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An endocannabinoid mechanism for stress-induced analgesia.
Hohmann et al.
Nature, 2005;435:1108 -
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
Piomelli et al.
CNS Drug Rev., 2006;12:21 -
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
Jayamanne et al.
Br.J.Pharmacol., 2006;147:281
Product Datasheets
Citations for URB 597
The citations listed below are publications that use Tocris products. Selected citations for URB 597 include:
6 Citations: Showing 1 - 6
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Neurexin1α differentially regulates synaptic efficacy within striatal circuits.
Authors: Marc V Et al.
Cell Rep 2021;34:108773
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Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
Authors: Morena Et al.
Neuropharmacology 2016;111:59
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Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine.
Authors: Vilela Et al.
J Neurosci 2015;2015:523418
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Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
Authors: Sardinha Et al.
Mediators Inflamm 2014;2014:978678
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Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Authors: Butti Et al.
Brain 2012;135:3320
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The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
Authors: Hamtiaux Et al.
BMC Cancer 2012;12:92
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