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UNC 1999

Catalog #: 4904
1 Citation Datasheet
Catalog # Availability Size / Price Qty
4904/10
4904/50
UNC 1999 | CAS No. 1431612-23-5 | EZH2 Inhibitor
1 Image
Description: Potent and selective EZH2/EZH1 inhibitor

Chemical Name: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

UNC 1999 is a potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 10 and 45 nM, respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.

Negative Control also available.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1999 is reviewed on the chemical probes website.

Technical Data

M.Wt:
569.74
Formula:
C33H43N7O2
Solubility:
Soluble to 100 mM in 1M HCl and to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1431612-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.
Other Product-Specific Information:

Product Datasheets

Citation for UNC 1999

The citations listed below are publications that use Tocris products. Selected citations for UNC 1999 include:

1 Citation: Showing 1 - 1

  1. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
    Authors: Chagraoui Et al.
    Nat Commun  2018;9:5375

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