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UNC 0642

Catalog #: 5132
3 Citations Datasheet
Catalog # Availability Size / Price Qty
5132/10
5132/50
UNC 0642 | CAS No. 1481677-78-4 | G9a/GLP Inhibitor
1 Image
Description: Potent and selective G9a and GLP inhibitor

Chemical Name: 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

UNC 0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM) that exhibits >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases. UNC 0642 reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM), and displays modest brain penetration in vivo.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC0642 is reviewed on the chemical probes website.

Technical Data

M.Wt:
546.7
Formula:
C29H44F2N6O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1481677-78-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0642 probe summary on the SGC website.

Product Datasheets

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Citations for UNC 0642

The citations listed below are publications that use Tocris products. Selected citations for UNC 0642 include:

3 Citations: Showing 1 - 3

  1. EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation.
    Authors: Xi Et al.
    Elife  2022;11
  2. Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma
    Authors: Bellamy Et al.
    Front Oncol  2020;10
  3. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis.
    Authors: Xin Et al.
    Cell  2019;176:1113-1127.e16

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