UCPH 101

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome.
   Okabe Y, Takahashi T, Mitsumasu C, Kosai K, Tanaka E, Matsuishi T
   PLoS ONE, 2012;7(4):e35354.
2. Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.
   Abrahamsen et al.
   J.Neurosci., 2013;33:1068
3. Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.
   Jensen et al.
   J.Med.Chem., 2009;52:912
4. Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).
   Erichsen et al.
   J.Med.Chem., 2010;53:7180
5. Excitatory amino acid transporters as potential drug targets.
   Bunch et al.
   Exp.Opin.Ther.Targets, 2009;13:719

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