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U 46619

Catalog #: 1932
9 Citations Datasheet
Catalog # Availability Size / Price Qty
1932/1
U 46619 | CAS No. 56985-40-1 | Prostanoid Receptor Agonists
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Description: Potent, stable thromboxane A2 (TP) receptor agonist
Alternative Names: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a

Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

Purity: ≥98%

Product Details
Citations (9)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

U 46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

Technical Data

M.Wt:
350.5
Formula:
C21H34O4
Solubility:
Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
56985-40-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for U 46619

The citations listed below are publications that use Tocris products. Selected citations for U 46619 include:

9 Citations: Showing 1 - 9

  1. Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats.
    Authors: Choi Et al.
    Scientific Reports  2016;6:31925
  2. A human platelet calcium calculator trained by pairwise agonist scanning.
    Authors: Lee and Diamond
    PLoS One  2015;11:e1004118
  3. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.
    Authors: Coleman Et al.
    Mol Pharmacol  2014;86:342
  4. Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence.
    Authors: Pike Et al.
    Sci Rep  2014;4:4705
  5. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Diabetes  2013;8:e66404
  6. Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats.
    Authors: White Et al.
    Br J Pharmacol  2013;168:785
  7. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.
    Authors: Davis Et al.
    Br J Pharmacol  2013;168:773
  8. S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
    Authors: Lacar Et al.
    PLoS One  2012;7:e31960
  9. Platelets present antigen in the context of MHC class I.
    Authors: Chapman Et al.
    J Immunol  2012;189:916

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