Home / Sphingosine-1-phosphate Receptor Antagonists / TY 52156

TY 52156

Catalog #: 5328
7 Citations Datasheet
Catalog # Availability Size / Price Qty
5328/10
5328/50
TY 52156 | CAS No. 934369-14-9 | Sphingosine-1-phosphate Receptor Antagonists
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Description: S1P3 receptor antagonist

Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide

Purity: ≥98%

Product Details
Citations (7)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TY 52156 is an S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Technical Data

M.Wt:
364.27
Formula:
C18H19Cl2N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
934369-14-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TY 52156

The citations listed below are publications that use Tocris products. Selected citations for TY 52156 include:

7 Citations: Showing 1 - 7

  1. S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation.
    Authors: Rosalinda Et al.
    Cells  2022;11
  2. Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
    Authors: Rosalinda Et al.
    Cell Physiol Biochem  2021;55:539-552
  3. Pro-Inflammatory Role of S1P3 in Macrophages.
    Authors: Heo and Im
    Biomol Ther (Seoul)  2019;
  4. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
    Authors: H?bner Et al.
    Nat Commun  2018;9:4860
  5. A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
    Authors: Ma Et al.
    Dev Cell  2017;41:366
  6. Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
    Authors: Schuhmann Et al.
    J Neurosci  2015;16:29454
  7. Fingolimod induces neuroprotective factors in human astrocytes.
    Authors: Hoffmann Et al.
    J Neuroinflammation  2015;12:184

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