Triacsin C
Chemical Name: (2E,4E,7E)-2,4,7-Undecatrienal nitrosohydrazone
Purity: ≥95%
Biological Activity
Triacsin C is an inhibitor of acyl-CoA synthetase. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation.
Tomoda et al.
J.Biol.Chem., 1991;266:4214 -
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Mashima et al.
J.Natl.Cancer.Inst., 2005;97:765 -
ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis
J Chen, C Ding, Y Chen, W Hu, Y Lu, W Wu, Y Zhang, B Yang, H Wu, C Peng, H Xie, L Zhou, J Wu, S Zheng
Oncogenesis, 2020;9(4):42.
Product Datasheets
Citation for Triacsin C
The citations listed below are publications that use Tocris products. Selected citations for Triacsin C include:
1 Citation: Showing 1 - 1
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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.
Authors: Lancaster Et al.
Cell Metab 2018;27:1096
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