tri-GalNAc-PEG3-Azide
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Description: Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
Purity: ≥90%
Biological Activity
tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.Technical Data
M.Wt:
1644.83
Formula:
C70H125N13O31
Solubility:
Soluble to 5 mg/ml in water
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
2925590-71-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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