Trazodone hydrochloride
Chemical Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
Purity: ≥99%
Biological Activity
Trazodone hydrochloride is a 5-HT2A and α1 adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Halliday et al.
Brain, 2017;140:1768 -
Proneurogenic effects of traz. in murine and human neural progenitor cells.
Bortolotto et al.
ACS Chem.Neurosci., 2017;8:2027
Product Datasheets
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