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TP-040

Catalog #: 7771 Datasheet
Catalog # Availability Size / Price Qty
7771/10
7771/50
TP-040 | CAS No. 2757254-99-0 | Hydrolase Inhibitors
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Description: Potent and selective O-GlcNAcase (OGA) inhibitor

Chemical Name: N-[(1-Methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

TP-040 is a potent and selective O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It increases the level of O-GlcNAcylated protein in human neuroblastoma SH-SY5Y cells (EC50 = 450 nM). It is suitable for in vivo studies and exhibits brain permeability.

Technical Data

M.Wt:
286.38
Formula:
C15H22N6
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2757254-99-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP-040 probe summary on the SGC website.

Product Datasheets

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