Tocriscreen Kinase Inhibitor 3.0
Biological Activity
Tocriscreen Kinase Inhibitor 3.0 compound library is a collection of 210 kinase inhibitors supplied pre-dissolved in DMSO (100 μL 10 mM solution). The Tocriscreen Kinase Inhibitor 3.0 Library contains compounds targeting >60 different kinases, including extensive coverage of well-established targets such as VEFGR and AKT, as well as novel targets such as Haspin and DYRK. The Tocriscreen Kinase Inhibitor 3.0 library is suitable for high-throughput screening (HTS), cell based high-content screening (HCS), target validation and assay development. Please view the kinase tree image for a closer look at the pharmacological diversity of this compound library.If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.
Scientific Data
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Kinase phylogenetic tree illustrating the pharmacological diversity of the Tocriscreen Kinase Inhibitor 3.0 Library. The 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library target over 230 kinases. Targets are evenly spread across all the major IUPHAR kinase subfamilies, with a mix of well-established targets such as VEFGR and AKT, and “dark” kinases such as CDK19 and DYRK1B. To view a larger PDF version of this image, please click on the 'kinase tree' link in the product description.
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Chemical diversity of the Tocriscreen Kinase Inhibitor 3.0 compound library. The images show the overlapping chemical space of the 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library (green dots) in relation to the chemical space occupied by the ChEMBL kinase inhibitors (grey dots). Each dot represents a unique fingerprint generated from each compound's 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library highlights the chemical diversity of this library.
Key Format and Product Details
- 96-well racks with TrakMate tubes & SepraSeal caps
- Pre-dissolved in DMSO
- Compounds arranged 80 per rack with 3 racks per library
- Many compounds are exclusive to Tocris
- Full chemical and biological data available
- Exceptional purity
Major IUPHAR kinase subfamilies covered by Tocriscreen Kinase Inhibitor 3.0 Library. TK (tyrosine kinase, 29%); CMGC (includes CDK, MAPK, GSK3 and CLK families, 19%); TKL (tyrosine kinase-like, 16%); AGC (includes PKA, PKG and PKC families, 11%); Atypical (7%); CAMK, (calcium/calmodulin-dependent protein kinases, 4%) and Other Kinases (includes CAMKK, CK1 and STE, 14%).
Request Compound List
A list of the compounds available in the Tocriscreen Kinase Inhibitor 3.0 can be requested in Excel or SD format via our Tocriscreen & Custom Library Inquiries form.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Product Datasheets
Citations for Tocriscreen Kinase Inhibitor 3.0
The citations listed below are publications that use Tocris products. Selected citations for Tocriscreen Kinase Inhibitor 3.0 include:
17 Citations: Showing 1 - 10
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Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging.
Authors: Haga Et al.
iScience 2024;27:109708
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Discovery of a CK2α'-biased ATP-competitive inhibitor from a high-throughput screen of an allosteric-inhibitor-like compound library.
Authors: Mudaliar Et al.
ACS Chem.Neurosci. 2024;
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Chemical genomics reveals targetable programs of human cancers rooted in pluripotency.
Authors: Orlando Et al.
Cell Chem.Biol. 2023;30:780
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Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery.
Authors: Gull Et al.
Cold Spring Harb.Protoc. 2022;4
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Discovery and characterization of multiple classes of human CatSper blockers.
Authors: Carlson Et al.
Chem Med Chem 2022;17:e202000499
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A screen of kinase inhibitors reveals a potential role of Chk1 in regulating Hydra head regeneration and maintenance.
Authors: Lee Et al.
Int J Dev Biol 2021;65:523
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Developments in the discovery and design of protein kinase D inhibitors.
Authors: Gilles Et al.
Chem.Med.Chem. 2021;16:2158
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Chemical manipulation of abscisic acid signaling: a new approach to abiotic and biotic stress management in agriculture.
Authors: Hewage Et al.
Adv.Sci. 2020;7:2001265
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NTRK1 is a positive regulator of YAP oncogenic function.
Authors: Yang Et al.
Oncogene 2019;38:2778
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Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells.
Authors: Chaudhari Et al.
Stem Cells 2019;37:306
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Cheminformatics tools for analyzing and designing optimized small-molecule collections and libraries.
Authors: Moret Et al.
Cell Chem Biol 2019;26:765
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EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions.
Authors: Wang Et al.
Cell Stem Cell 2019;24:419
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A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.
Authors: Azad Et al.
Nat Commun 2018;9:1061
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GSK3 is a negative regulator of the thermogenic program in brown adipocytes.
Authors: Markussen Et al.
Sci.Rep. 2018;8:3469
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Protocols for the design of kinase-focused compound libraries.
Authors: Jacoby Et al.
Mol.Inform. 2018;37:e1700119
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Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
Authors: Tomilov Et al.
Pharmacol Res 2018;137:89
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1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features.
Authors: Moeschler Et al.
Viruses 2018;10:E306
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