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Tocriscreen 2.0 Max

Catalog #: 7150
22 Citations Datasheet
Catalog # Availability Size / Price Qty
7150/1 SET
Tocriscreen 2.0 Max | Compound Libraries
1 Image
Description: Bioactive compound library for high-throughput screening, high-content screening, target validation and assay development; comprised of 1280 biologically active compounds (250 μL 10 mM DMSO solutions)
Product Details
Citations (22)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Tocriscreen 2.0 Max is a library of 1280 biologically active compounds from the Tocris catalog. Covers a wide range of pharmacological targets and research areas. Compounds are supplied pre-dissolved in 250 μL 10 mM DMSO solutions. A smaller volume is available as Tocriscreen 2.0 Mini (Cat. No. 7151) and Tocriscreen 2.0 Micro (Cat. No. 7152).

This library replaces the Tocriscreen Plus (Cat. No. 5840).

For more information on the Tocriscreen 2.0 Compound Libraries, please download our informative flyer.

If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.

Key Format and Product Details

  • 96-well racks with Matrix storage tubes & SepraSeal caps
  • Compounds arranged 80 per rack with 16 racks per library
  • Pre-dissolved in DMSO
  • Many compounds are exclusive to Tocris
  • Unique library with low overlap
  • Full chemical and biological data available
  • Exceptional purity
Target Classes Covered by the Tocriscreen 2.0 Compound Library

The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 27%), non-kinase enzymes (21%), kinases including enzyme-linked receptors (20%), ion channels (13%), cell biology targets (9%), nuclear receptors (6%), and transporters and other pharmacological targets (5%).

Request Compound List

A list of the compounds available in the Tocriscreen 2.0 Max can be requested in Excel or SD format via our Tocriscreen & Custom Library Inquiries form.

Technical Data

Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
The Compound list for this product may be requested from www.tocris.com/screening

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
SDS

Citations for Tocriscreen 2.0 Max

The citations listed below are publications that use Tocris products. Selected citations for Tocriscreen 2.0 Max include:

22 Citations: Showing 1 - 10

  1. Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
    Authors: Sichler Et al.
    Toxicol.Letter.  2024;394:23
  2. An extensively validated whole-cell biosensor for specific, sensitive and high-throughput detection of antibacterial inhibitors targeting cell-wall biosynthesis.
    Authors: Galarion Et al.
    J.Antimicrob.Chemother.  2023;78:646
  3. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells.
    Authors: Li Et al.
    iScience  2023;26:106156
  4. An image-based high-content screening for compounds targeting Toxoplasma gondii repurposed inhibitors effective against the malaria parasite Plasmodium falciparum.
    Authors: Honfozo Et al.
    Front.Cell.Infect.Microbiol.  2023;13:1102551
  5. Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform.
    Authors: Gruber Et al.
    Hum.Reprod.  2022;:deac007
  6. HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E-mutant high-grade glioma.
    Authors: Sasame Et al.
    Clin.Cancer Res.  2022;28:2425
  7. Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery.
    Authors: Gull Et al.
    Cold Spring Harb.Protoc.  2022;
  8. Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
    Authors: Ehteda Et al.
    Cell Rep  2021;35:108994
  9. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells
    Authors: Chen Et al.
    Nat.Methods  2021;18:528
  10. Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma.
    Authors: Endersby Et al.
    Sci Transl Med  2021;13:eaba7401
  11. Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody.
    Authors: Tanaka Et al.
    Sci Rep  2021;11:1712
  12. Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists.
    Authors: Tian Et al.
    J Med Chem  2020;63:6164
  13. High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement.
    Authors: Xie Et al.
    Biochem.Biophys.Res.Commun.  2020;521:232
  14. Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
    Authors: Telpoukhovskaia Et al.
    Science Reports  2020;10:13688
  15. Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.
    Authors: Lake Et al.
    BioRXiv  2020;
  16. Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant.
    Authors: Diamantopoulou Et al.
    Elife  2019;8:e44889
  17. A library screening strategy combining the concepts of MS binding assays and affinity selection mass spectrometry.
    Authors: Gabriel Et al.
    Front Chem  2019;7:665
  18. Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays.
    Authors: Danthi Et al.
    SLAS Discov  2019;24:111
  19. An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.
    Authors: Trogden Et al.
    FASEB J.  2018;32:2841
  20. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  21. Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth.
    Authors: Dittmar Et al.
    mSphere  2016;1:e00042
  22. Tubulin is a molecular target of the Wnt-activating chemical probe.
    Authors: Fukuda Et al.
    BMC Biochemistry  2016;17:9

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