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TL 13-22

Catalog #: 6747 Datasheet
Catalog # Availability Size / Price Qty
6747/5
TL 13-22 | CAS No. 2229036-65-9 | Active Degrader Negative Controls
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Description: Negative control for TL 13-12 (Cat. No. 6744)

Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide

Purity: ≥98%

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Biological Activity

TL 13-22 is a negative control for TL 13-12 (Cat. No. 6744). Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC50 = 0.54 nM)

Technical Data

M.Wt:
947.5
Formula:
C45H55ClN10O9S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2229036-65-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Chemically induced degradation of anaplastic lymphoma kinase (ALK).
    Powell et al.
    J.Med.Chem., 2019;61:4249

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