Tilfrinib
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Description: Potent and selective breast tumor kinase (Brk) inhibitor
Chemical Name: 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Purity: ≥98%
Biological Activity
Tilfrinib is a potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.Technical Data
M.Wt:
275.3
Formula:
C17H13N3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1600515-49-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from Martin-Luther-Universität-Halle-Wittenburg
Background References
-
Discovery of 4-anilino α-carbolines as novel Brk inhibitors.
Mahmoud et al.
Bioorg.Med.Chem.Lett., 2014;24:1948
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