THIP hydrochloride
Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Purity: ≥98%
Biological Activity
THIP hydrochloride is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, Rudolph U, Swinny J
, 2014;0(0):. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
GABAC receptors: relatively simple transmitter-gated ion channels?
Johnston
TiPS, 1996;17:319 -
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Krogsgaard-Larson
J.Med.Chem., 1983;26:895 -
Gaboxadol. Lundbeck/Merck
Huckle
Curr.Opin.Investig.Drugs, 2004;5:766 -
Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine.
Krogsgaard-Larson
Drugs Future., 1984;9:597
Product Datasheets
Citations for THIP hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for THIP hydrochloride include:
13 Citations: Showing 1 - 10
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Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive.
Authors: Ki and Lim
Elife 2019;8
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HIV gp120 upregulates tonic inhibition through α5-containing GABAARs.
Authors: Green and Thayer Et al.
Neuropharmacology 2019;149:161
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δ-subunit containing GABAA receptors modulate respiratory networks.
Authors: Montandon
Sci Rep 2017;7(1):18105
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Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
Authors: Patel Et al.
J Neurophysiol 2016;36:607
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Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
Authors: Tong Et al.
J Neurosci 2015;35:16142
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Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Authors: Seifi Et al.
Nature 2014;34:10361
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Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
Authors: Szemes Et al.
Mol Brain 2013;6:33
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Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
Authors: Ramaker Et al.
Neuropharmacology 2012;63:555
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Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Authors: Asiedu Et al.
J Pain 2012;13:546
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Potentiating action of PropF. at GABAA receptors of retinal bipolar cells.
Authors: Yue Et al.
Invest Ophthalmol Vis Sci 2011;52:2497
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Blindsight depends on the lateral geniculate nucleus.
Authors: Schmid Et al.
PLoS One 2010;466:373
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Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
Authors: Krook-Magnuson Et al.
J Neurosci 2008;100:932
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Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice.
Authors: Glykys
J Neurophysiol 2006;95:2796
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