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Thiamet G

Catalog #: 4390
4 Citations Datasheet
Catalog # Availability Size / Price Qty
4390/10
Thiamet G | CAS No. 1009816-48-1 | Hydrolase Inhibitors
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Description: Potent O-GlcNAcase inhibitor

Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Thiamet G is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Technical Data

M.Wt:
248.3
Formula:
C9H16N2O4S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at -20°C
CAS No:
1009816-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Thiamet G

The citations listed below are publications that use Tocris products. Selected citations for Thiamet G include:

4 Citations: Showing 1 - 4

  1. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis.
    Authors: Taparra Et al.
    J Clin Invest  2018;128:4924
  2. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.
    Authors: Jonathan C Et al.
    Nat Neurosci  2015;18:1183-9
  3. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
    Authors: Hayakawa Et al.
    J Biol Chem  2013;288:17099
  4. Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation.
    Authors: Maury Et al.
    Stem Cell Res  2013;11:926

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