Thalidomide 4'-ether-PEG2-alkyne
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione
Purity: ≥95%
Biological Activity
Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.This product has been recently renamed. The previous name for this product was Thalidomide - linker 5
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Degradation of the BAF complex factor BRD9 by heterobifunctional ligands.
Remillard et al.
Angew.Chem.Int.Ed.Engl., 2017;56:5738
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Thalidomide 4'-ether-PEG2-alkyne
There are currently no reviews for this product. Be the first to review Thalidomide 4'-ether-PEG2-alkyne and earn rewards!
Have you used Thalidomide 4'-ether-PEG2-alkyne?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
