TGX 221
Chemical Name: 7-Methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥98%
Biological Activity
TGX 221 is a potent and selective PI 3-kinase β inhibitor (IC50 values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Phosphoinositide 3-kinase p110? negatively regulates thrombopoietin-mediated platelet activation and thrombus formation
TA Blair, SF Moore, TG Walsh, JL Hutchinson, TN Durrant, KE Anderson, AW Poole, I Hers
Cell. Signal., 2018;0(0):. -
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe et al.
Blood, 2005;106:1432 -
PI 3-kinase p110β: a new target for antithrombotic therapy.
Jackson et al.
Nat.Med., 2005;11:507
Product Datasheets
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