TG 003

Catalog # Availability Size / Price Qty
4336/10
4336/50
TG 003 | CAS No. 719277-26-6 | Cdc2-like Kinase Inhibitors
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Description: Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B

Chemical Name: (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

Technical Data

M.Wt:
249.33
Formula:
C13H15NO2S
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
719277-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for TG 003

The citations listed below are publications that use Tocris products. Selected citations for TG 003 include:

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