Terbinafine hydrochloride

Catalog #: 6484
1 Citation Datasheet

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Terbinafine hydrochloride | CAS No. 78628-80-5 | Two-P Potassium Channels Activators

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Description: Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase

Chemical Name: N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride

Purity: ≥98%

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Product Details

Citations (1)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Terbinafine hydrochloride is a selective TASK3 activator (pEC₅₀ = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

Technical Data

M.Wt:

327.89

Formula:

C₂₁H₂₅N.HCl

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

78628-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.
Petranyi et al.
Science, 1984;224:1239
Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.
Wright et al.
Biochem.Biophys.Res.Commun., 2017;493:444

Product Datasheets

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SDS

Citation for Terbinafine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Terbinafine hydrochloride include:

1 Citation: Showing 1 - 1

Modulation of TASK-1/3 channels at the hypoglossal motoneuron pool and effects on tongue motor output and responses to excitatory inputs in vivo: implications for strategies for obstructive sleep apnea pharmacotherapy.
Authors: Richard L Et al.
Sleep 2021;44

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