Tempol
Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Purity: ≥99%
Biological Activity
Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Tempol reduces γ-radiation-induced damage in hematopoietic stem cells in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of vascular smooth muscle tone by adipose-derived contracting factor.
Meyer, Matthias, Fredette, Natalie, Barton, Matthias, Prossnitz, Eric R
PLoS ONE, 2013;8(11):e79245. -
Sestrin 2 protein regulates platelet-derived growth factor receptor beta (Pdgfrbeta) expression by modulating proteasomal and Nrf2 transcription factor functions.
Tomasovic A, Kurrle N, Surun D, Heidler J, Husnjak K, Poser I, Schnutgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H
J Biol Chem, 2015;290(15):9738-52. -
Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium.
Lowry J, Brovkovych V, Zhang Y, Skidgel R
J Biol Chem, 2013;288(6):4174-93. -
Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model.
Deng-Bryant et al.
J.Cereb.Blood Flow Metab., 2008;28:1114 -
The superoxide scavenger TEMPOL induces urok. receptor (uPAR) expression in human prostate cancer cells.
Francis and Sehgal
Mol.Cancer, 2006;5:21
Product Datasheets
Citations for Tempol
The citations listed below are publications that use Tocris products. Selected citations for Tempol include:
9 Citations: Showing 1 - 9
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Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
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Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension.
Authors: Hood Et al.
Hypertension 2016;68:796
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The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.
Authors: Somanna Et al.
J Cell Physiol 2016;231:1130
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Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions.
Authors: Tomasovic Et al.
Brain Res 2015;NULL
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Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
Authors: Beggs Et al.
Toxicology 2015;331:35
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p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.
Authors: Senturk Et al.
Proc Natl Acad Sci U S A 2014;111:E3287
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Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
Authors: Nesuashvili Et al.
Mol Pharmacol 2013;83:1007
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Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.
Authors: Valente Et al.
Am J Physiol Heart Circ Physiol 2012;303:H282
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Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
Authors: Ruparel Et al.
J Biol Chem 2012;153:2031
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