TCS ERK 11e
Chemical Name: 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
Purity: ≥98%
Biological Activity
TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control.
Aronov et al.
J.Med.Chem., 2009;52:6362
Product Datasheets
Citations for TCS ERK 11e
The citations listed below are publications that use Tocris products. Selected citations for TCS ERK 11e include:
2 Citations: Showing 1 - 2
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Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses.
Authors: Kai Et al.
Int J Mol Sci 2022;23
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The cellular thermal shift assay for evaluating drug target interactions in cells.
Authors: Rozbeh Et al.
Nat Protoc 2014;9:2100-22
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