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TCS 359

Catalog #: 2591 Datasheet
Catalog # Availability Size / Price Qty
2591/10
2591/50
TCS 359 | CAS No. 301305-73-7 | Flt-3 Inhibitors
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Description: Potent FLT3 inhibitor

Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide

Purity: ≥99%

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Biological Activity

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).

Technical Data

M.Wt:
360.43
Formula:
C18H20N2O4S
Solubility:
Soluble to 30 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
301305-73-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
    Patch et al.
    Bioorg.Med.Chem.Lett., 2006;16:3282

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