TC-S 7003

Catalog #: 3567 Datasheet

Catalog #	Availability	Size / Price	Qty
3567/10

TC-S 7003 | CAS No. 847950-09-8 | Src Family Kinase Inhibitors

1 Image

Description: Potent Lck inhibitor

Chemical Name: 6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one

Purity: ≥98%

View All Products for Src Family Kinase Inhibitors

Product Details

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-S 7003 is a potent inhibitor of lymphocyte specific kinase (Lck). IC₅₀ values are 0.007, 0.021, 0.042 and 0.20 μM for Lck, Lyn, Src and Syk kinases respectively. Displays >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Inhibits T cell proliferation in vitro and inhibits arthritis in two in vivo models. Orally active.

Technical Data

M.Wt:

530.62

Formula:

C₃₁H₃₀N₈O

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

847950-09-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory
Martin et al.
J.Med.Chem., 2008;51:1637

Product Datasheets

COA view current batch

SDS

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TC-S 7003

There are currently no reviews for this product. Be the first to review TC-S 7003 and earn rewards!

Have you used TC-S 7003?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.