TC-G 24

Catalog #: 4353 Datasheet

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4353/50

TC-G 24 | CAS No. 1257256-44-2 | GSK-3 Inhibitors

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Description: Potent and selective GSK-3β inhibitor

Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-G 24 is a potent GSK-3β inhibitor (IC₅₀ = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data

M.Wt:

330.73

Formula:

C₁₅H₁₁ClN₄O₃

Solubility:

Soluble to 10 mM in DMSO with gentle warming

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1257256-44-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.
Khanfar et al.
J.Med.Chem., 2010;53:8534

Product Datasheets

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