TC-G 1005

Catalog #: 5129
1 Citation Datasheet

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TC-G 1005 | CAS No. 1415407-60-1 | GPBA Receptor Agonists

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Description: Potent and selective GPBA receptor (TGR5) agonist

Chemical Name: (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-G 1005 is a potent and selective GPBA agonist (EC₅₀ values are 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor). TC-G 1005 increases plasma GLP-1 levels and reduces blood glucose in mice. Orally bioavailable.

Technical Data

M.Wt:

399.48

Formula:

C₂₅H₂₅N₃O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1415407-60-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists.
Duan et al.
J.Med.Chem., 2012;55:10475

Product Datasheets

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Citation for TC-G 1005

The citations listed below are publications that use Tocris products. Selected citations for TC-G 1005 include:

1 Citation: Showing 1 - 1

Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents.
Authors: Urso Et al.
Am.J.Physiol.Lung Cell.Mol.Physiol. 2020;318:L264

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