TC-E 5002
Chemical Name: N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine
Purity: ≥98%
Biological Activity
TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
Suzuki et al.
J.Med.Chem., 2013;56
Product Datasheets
Citation for TC-E 5002
The citations listed below are publications that use Tocris products. Selected citations for TC-E 5002 include:
1 Citation: Showing 1 - 1
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Authors: David E Et al.
Mol Cell 2022;82:2472-2489.e8
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